Clinical Trials - Depression and Bipolar Support Alliance

Many people think that participating in a clinical trial means they will get better treatment for their illness. While this may be true, it's important to remember that a clinical trial is conducted for research purposes -- it does not ensure better or safer treatment.

Taking part in a trial does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a clinical trial is to science first and to the patient second.

DBSA, its advisors and consultants do not endorse or recommend the use of any specific treatment or medication. For advice about specific treatment or medication, patients should consult their physicians and/or mental health professionals.

Description:
The present study is open to males and females 18 years old and older who meet diagnostic criteria for bipolar. This study examines the efficacy of combination therapy for the treatment of Bipolar disorder using an experimental medication in conjunction with a traditional mood stabilizer. The trial may last for up to 18 months. All study related care provided at no cost and participants are reimbursed for their time and travel.

Longitudinal Evaluation of the Efficacy and Safety of Mood Stabilizers in Dual Diagnosis Bipolar Rapid Cycling

Description:
This study recruits males and females age 18 and older who currently meet diagnostic criteria for rapid cycling bipolar disorder (type I or II) and who have met the criteria for substance abuse or dependence of cocaine, marijuana and/or alcohol within the past six months. Patients are initially stabilized on dual therapy of mood stabilizers and then randomly assigned to double-blind treatment with either mood stabilizer monotherapy or continued dual therapy. Patients remain in the study for six months or until they experience a relapse. Patients in this study are required to bring a friend or family member to all study visits as well as attend chemical dependency services. Subjects receive study-related care at no cost.

Description:
This study recruits males and females age 18 and older who currently meet diagnostic criteria for rapid cycling bipolar disorder (type I or II) and who have met the criteria for substance abuse or dependence of cocaine, marijuana and/or alcohol within the past six months. Patients begin treatment with a combination of mood stabilizers. Once these medications are tolerated, they are randomly assigned to double-blind treatment with another mood stabilizer or placebo. Patients remain in this study until they experience a marked bimodal response for four consecutive weeks. Subjects receive study-related care at no cost.

Double-Blind, Placebo-Controlled Mood Stabilizer in Bipolar I or Bipolar II Depression Previously Diagnosed and Treated as Recurrent Major Depression

Description:
This study recruits males and females aged 18 – 70 who currently meet diagnostic criteria for bipolar I or bipolar II disorder and are currently experiencing an episode of major depression. Patients are randomized to double-blind treatment with a mood stabilizer or placebo and remain in the study for up to six weeks. This six-week double-blind treatment period is followed by an open-label treatment period of six months duration. Subjects receive study-related care at no cost.

A Multicenter, Randomized, Double-Blind, Placebo Controlled Study of Antipsychotic Monotherapy in the Treatment of Acutely Manic Patients with Bipolar Disorder I

Description:
This study recruits adult subjects who are diagnosed with Bipolar I disorder, and presently experiencing an episode of mania requiring hospitalization. Participants must be willing to stay in the hospital for the first portion of the study. The study requires people that have had at least one previous manic episode. Patients are initially randomized to antipsychotic or placebo vs. another antipsychotic or placebo for the first 3 weeks of the trial. After the initial phase of the study patients are assigned to active medication and are followed for an additional 12-week maintenance phase. Subjects receive study-related care at no cost.

Description:
Linden Research Consultants is conducting a clinical trial for people 18 and older who are suffering from Bipolar disorder Type 1, Manic or Mixed. Participants in this trial will receive at no charge: Physical Exam, Lab Work, & Investigational Medication. Compensation Provided.

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Bifeprunox in the Treatment of Depression in Outpatients with Bipolar Disorder

Description:
The objective of this study is to investigate if 8 weeks of treatment with flexible doses of a psychotropic medication (20 to 40 mg/day) is superior to treatment with placebo in depressed outpatients with bipolar disorder.

Those male or female, between the ages of 18-65, with a diagnosis of bipolar disorder and who are currently experiencing a depressive episode are eligible to participate.

This study is currently underway at locations in twenty five states.

A randomized, double-blind, placebo-controlled study of a mood stabilizer in bipolar disorder with mild to moderate manic symptoms

Description:
This is an eight week placebo controlled study using one medication (an anti-convulsant also approved as a mood stabilizer). Fifty percent of subjects receive placebo (sugar pill) and half receive active drug. Participants receive all examinations, labs and tests at no costs. Participants are reimbursed for their time and travel expenses. Our hours are 8am-5pm Monday through Friday.

A randomized, double-blind, placebo-controlled study of an anti-psychotic medication bipolar disorder with current moderately severe anxiety and lifetime panic or generalized anxiety disorder

Description:
This is an eight week study. It is a randomized, double-blind, placebo-controlled study of an atypical anti-psychotic medication bipolar disorder with current moderately severe anxiety and lifetime panic or generalized anxiety disorder. Fifty percent of subjects will receive placebo (sugar pill) and the other half will receive active drug (atypical anti-psychotic). All examinations, labs, and tests are conducted at no charge. Subjects are reimbursed for their time and travel. Our office hours are 8am-5pm Monday through Friday.

Description:
We are examining the use of an antipsychotic in the treatment of patients experiencing increases in symptoms of depression or hypomania. In this study, patients will add the study medication or a placebo to their current stable medication regimen for a period of one week, after which all patients will receive the study medication for one week while being monitored by a psychiatrist. Patients will be compensated for their time and expenses.

Description:
We offer no treatment, simply the opportunity to contribute to the knowledge base on bipolar disorder and how it might be passed from one generation of a family to another. Participants who meet the screening criteria (Bipolar I with a severe manic episode) are asked to give a small amount of blood via venipuncture (about 3 Tbs) and do an interview on their illness and family history. Interviews can be done over the phone and blood samples can be obtained at a local lab if a participant can't come to the medical center. Participants must be at least 16 years old and have some knowledge of their family's medical history. Reimbursement for their time is offered upon completion of the interview and blood draw.

Description:
It is a Multicenter, Randomized, Parallel-group, Double-Blind, Phase III Comparison of the Efficacy and Safety of an Antipsychotic to Placebo When Used in Conjunction with Mood Stabilizers in the Maintenance Treatment of Bipolar I Disorder in Adult Patients.

A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitve Dysfunction in Bipolar Disorder

Description:
FORGETFUL? HAVING TROUBLE CONCENTRATING?

Clinical research trial for patients with bipolar disorder who are currently not experiencing symptoms but report difficulties with memory or concentration, to test whether cognitive function is improved by galantamine.

This is a 25 week outpatient study with study-related care provided free of charge and travel costs reimbursed.

Description:
We are examining the use of an atypical antipsychotic in the treatment of patients currently experiencing both hypomania and depressive symptoms (dysphoric hypmania). In this study, after an initial evaluation phase, patients will be instructed to add the study atypical antipsychotic or a placebo to their current stable medication regimen for a period of eight weeks while being monitored by a psychiatrist using clinical and laboratory measures.

Description:
Mood stabilizers have become an established treatment for the many manifestations of bipolar disorder, and preliminary data suggest that the study mood stabilizer has potential efficacy in the treatment of depressive symptoms. In this study, after an initial evaluation, patients will receive the study mood stabilizer for 8 weeks while monitored by a psychiatrist, using clinical and laboratory measures.

A Multicenter, Randomized, Double-Blind, Placebo Controlled Study of an Atypical Antipsychotic in the Treatment of Patients with Bipolar I Disorder with a Major Depressive Episode

Description:
The Stanford Bipolar Disorders Clinic is seeking participants for a new research study testing the use of an atypical antipsychotic in the treatment of depression. Participants will be randomly assigned to receive the atypical antipsychotic or placebo for eight weeks. After the initial 8-week period, participants will receive free treatment with the atypical antipsychotic for a period of 26 weeks. For this study there is no charge for assessment, physician visit, or study medication.

This study provides 2 ½ years of outpatient pharmacological treatment and 2 months of family therapy, at no cost, to depressed bipolar patients with a history of suicide attempt. There is no placebo group, and the medications used are FDA-approved mood stabilizers and antidepressants.

GlaxoSmithKline (GSK) is sponsoring clinical research studies to evaluate the effectiveness of a medication for treating depression in patients with bipolar disorder. This medication is currently approved by the FDA for the maintenance treatment of bipolar disorder; however, less is known about its use for acute treatment of bipolar depression. Patients are randomly assigned to receive either the medication or a placebo for eight weeks. If eligible, patients will come to the clinic approximately once a week during the treatment phase of the study, and once more for a follow-up visit after the treatment. To be eligible, a patient must be at least 18 years old, experiencing depression, and have a diagnosis of bipolar disorder. There are no costs to the patient for study medication, study visits or study procedures. Participation is entirely voluntary and patients may withdraw from the study at any time for any reason. To enroll or for more information, please refer to the following websites:

Description:
Washington University School of Medicine in St. Louis, in collaboration with 10 other national research centers across the United States, is conducting a study to identify the environmental and genetic markers that may be responsible for Bipolar 1 Disorder. A Certificate of Confidentiality has been received from the federal government that ensures that all information will be strictly confidential. Data will be assigned a code number and the master list linking the code number and your identity will be kept separate from the research data. This is not a clinical drug trial or treatment study.

Description:
If you or someone you love is depressed and between the ages 18 - 75, you may be eligible for a state-of-the art brain imaging study. We will provide up to 6 months of outpatient treatment for Unipolar and Bipolar Depression at no cost to the patient. One night stay at the Medical Center may be necessary. Inpatient treatment also available.

Description:
A clinical trial evaluating the effectiveness of cognitive behavioral group therapy for individuals with Bipolar Disorder. This is a randomized study, so some people may be assigned to the treatment group and some assigned to assessment only. Either way, participation is valuable in improving the standards of treatment for bipolar disorder. This program does not replace any counseling, psychotherapy or mental health services you are currently receiving and it does not involve any changes to your medication. The group is held at Pacific Graduate School of Psychology, Palo Alto, CA. Assessment and group therapy are available at no cost.

Eligibility:
Consumers with a diagnosis of Bipolar I Disorder, currently receiving treatment from a psychiatrist, and taking a mood stabilizing medication may be eligible

Enrollment Contact:
Shilpa Reddy, Project Coordinator
Phone: (650) 843-3515
Email: sreddy@pgsp.edu
Web site: http://www.pgsp.org/bipolar.htm

Description:
This study will compare the effects of a mood stabilizer and a second generation antipsychotic in the treatment of pediatric bipolar disorder. The study is being conducted at the University of Illinois at Chicago through the Pediatric Bipolar Research Program. Qualifying participants between the ages of 5 and 18 and diagnosed with bipolar disorder are asked to come to our clinic in the near-south area of Chicago 7 times for approximately 3 hours of interviews and assessments. Some visits will require a minimal amount of blood to be drawn. Clinical services and parking are free, and you will be paid a $35 stipend for your participation.

Qualifications:
Participants must be between the ages of 5 and 18 and diagnosed with bipolar disorder.

Enrollment Contact:
Ryan Shaw, (312) 413-1710
Email: rshaw@psych.uic.edu

Enrollment Deadline: August, 2008

Child & Adolescent Bipolar Disorder Study

Description:
The National Institute of Mental Health is seeking boys and girls ages 6 to 17 to participate in a study of bipolar disorder in children and adolescents. The study
includes a 5-day outpatient assessment and infrequent research follow-up visits
over 4 years at the NIH Clinical Center in Bethesda, Md. Thorough evaluation at NIMH provided free of charge. Travel and lodging expenses paid for by NIMH.

• In treatment with a psychiatrist for bipolar disorder
• On stable medications for the first 6 weeks of the study
• Able to fill out daily self rating forms and cooperate with study procedures (includes genetics study, MRI, psychological testing, and others)

Enrollment Contact:
National Institute of Mental Health
National Institutes of Health
Department of Health & Human Services
Call: 301-496-5645
(TTY: 1-866-411-1010)

Chronic Mood Problems in Children & Adolescents

Description:
NIMH is offering a treatment study of severe mood or behavioral problems in children and adolescents. All participants receive clinical and psychological assessments including an inpatient assessment during which children will be withdrawn from medication), treatment with a mood stabilizer, and brain imaging (no radiation). Participants may receive placebo for part of the study. Problems must be present for at least 1 year and have started before age 12. Evaluation & participation provided free of charge. Travel expenses paid.

Qualifications:
Participants must be 7-17 years old with:

• Chronic abnormal mood (severe anger, sadness or irritability)
• "Hyper" behavior (easily distracted, physically active,
trouble sleeping, fast thoughts/speech)
•Trouble handling frustration (severe temper tantrums & rages)

Enrollment Contact:
National Institute of Mental Health
National Institutes of Health
Department of Health & Human Services
Call: 301-496-5645
(TTY: 1-866-411-1010)

Description:
The National Institute of Mental Health is conducting a study for treatment-resistant bipolar disorder. Participants will receive: clinical & psychological assessments (including an inpatient assessment during which children will be withdrawn from medication); treatment with an antipsychotic or placebo; and brain imaging (no radiation.) All procedures are free of cost. Travel expenses are paid for.

Qualifications:
Participants must be between the ages of 8-17 with bipolar disorder and not have done well on lithium, sodium valproate, carbamazepine and at least one of the newer neuroleptics, as well as a combination of two of these medications.

Enrollment contact:
Call: Robinder Bhangoo, M.D., Ellen Leibenluft, M.D.
(301) 496-8381 or TTY 1-866-411-1010
National Institute of Mental Health
National Institutes of Health, Department of Health & Human Services

Treatment of Early Age Mania ages 6- 14 years

Description:
- Diagnosis of Bipolar I (manic or mixed state) or mania
- 8 weeks; 8 -week extension for partial or non- responders; 6 month follow up
- Outpatient only (no inpatient at baseline or substance dependency)
- Randomized drug based on prior medicinal history; 3 groups will be formulated based on whether baseline is antimatic drug free, on one study drug with partial response or on one study drug with poor response.
- Exclusions are Schizophrenia, PDD, IQ less than 70, pregnancy or major medical or neurological disease.

Description: If you are interested in participating in a study committed to improving the treatment of patients with bipolar disorder, please contact us. With your help, we hope to develop new strategies for treatment of bipolar depression and relapse prevention. Additionally, we hope to answer many important questions related to quality of life and economic outcomes.

Study Medication Versus Placebo As Add-on Treatment in Subjects With Bipolar Disorder in the Outpatient Setting.

Description: This is a 12-week study with the primary objective to evaluate the efficacy and safety of the addition of the study medication in subjects with Bipolar disease already taking a mood stabilizer.

Description: If you have Mania associated with Bipolar Disorder and are not adequately responding to the usual medications you may be eligible to participate in a research study testing an investigational medicine. You may receive medication at no cost and possibly improve your Bipolar Mania. To participate you must have Bipolar Disorder Type 1, be between 18 and 70 years of age and be in good health.

Contact
Suburban Research Associates
600 North Jackson
Media, PA 19063
Phone: (610) 891-9024 ext. 102
e-mail: amy@suburbanpsych.com

Description: Dr. Linda Harper, with CNS Heatlhcare is offering screenings for participation in a research study of an investigational medication to those experiencing symptoms of manic depression, who are also already on a mood stabilizer. Eligible participants, between 18 and 70 years of age, will receive a comprehensive psychiatric examination and study medication at no cost.

Description: The UCLA Mood Disorders Research Program is currently looking for people recovering from a manic or hypomanic episode to participate in a study assessing why some people return to work easily and others do not. The goal of this research study is to help us have a better understanding of why people who have bipolar disorder may recover from their symptoms of mania or hypomania, but do not recover fully in other areas of life, such as getting back to work or in their relationships with others.

This study is for individuals with bipolar disorder, type 1, who are between the ages 18-65. The study may last up to 18 months and individuals are seen monthly by our study psychiatrist and research assistants to assess mood, medication management, and functional recovery. Participants receive $360 for completion of the study, which is paid on a graduated scale per visit. Psychiatric care (mood and medication management) and mood stabilizer will be provided free of charge to subjects who choose to receive their care and mood stabilizer from our research project.

Description: The Pacific Graduate School of Psychology under a grant from The Health Trust is studying the effectiveness of cognitive behavioral therapy to address mood management problems for clients with bipolar disorder. This specialized treatment is targeted toward enhancing treatment adherence, medication compliance and improving clients’ mood stability, overall psychosocial functioning and quality of life. This treatment program involves 16 weeks of group treatment using a cognitive behavioral approach with continuing support for up to one year. These services are provided at no cost to clients living in Santa Clara County, California. In order to be eligible, clients must have a diagnosis of Bipolar I disorder and need to be under the care of a psychiatrist and receiving appropriate medication management. Treatment is provided at the Pacific Graduate School of Psychology Clinic in Palo Alto, California. Because this is a study that uses random assignment you may be assigned to an "Assessment Only" condition involving regularly initial and follow-up interviews and no active treatment.

Have you AND a family member ever been DEPRESSED?

Description:
Have you AND a family member ever been DEPRESSED? We want to learn more about how Major Depression is inherited.

You may be eligible to participate in a National Institute of Mental Health study if you:

Participation involves medical and psychiatric evaluations and giving a small blood sample.

Contact:
Columbia University – New York State Psychiatric Institute
(212) 543-6297
sibhealth@childpsych.columbia.edu

All Inquiries Are Strictly Confidential.

A Randomized Double-Blind Comparison of Atomoxetine versus Fluoxetine in Depressed Individuals who are Homozygous for the Short Allele of the Serotonin Transporter

Description:
Do you know a woman who feels sad, down, or blue most or all of the time?

These symptoms may be signs of clinical depression. Clinical depression can be expressed as feelings of sadness, a loss of energy or interest in regular activities, or feelings of guilt, hopelessness and helplessness. If someone you know has been experiencing any of these symptoms for more than two weeks, they may be interested in a clinical research study at McLean Hospital.

Researchers are currently recruiting depressed women for a study on the effect of genetics on response to different FDA-approved medications. Participation in the study involves taking study medication for 10 weeks, having blood drawn one time, and having two MRI scans of the brain.

Participants must be women between the ages of 18 and 55 who are currently depressed but are not taking any antidepressant medications. The study medication will be provided free of charge for the ten weeks of the study, and participants will be compensated up to $250 for their participation.

If someone you know may be appropriate for this study, please email Meghan at mshanahan@mclean.harvard.edu for more information, and refer to the “Genetics and Depression study.”

Description:
The Psychosocial Research and Depression Clinic in the Department of Psychiatry at The University of Texas Southwestern Medical Center at Dallas is conducting research on cognitive therapy to treat people who have been depressed more than once in their lives. Cognitive therapy is a short-term, talking therapy that focuses on negative patterns of thinking and develops coping skills.

Eligible individuals receive 16 or 20 sessions of cognitive therapy over 12 weeks. Evaluation and treatment are provided at no cost. After 16 or 20 sessions of therapy, eligible individuals will be followed for 8 more months and receive booster sessions of cognitive therapy, medication (Prozac), or sugar pill placebo.

The study will address whether “booster sessions” or medication will help individuals avoid relapse (return) of depression. Participation is strictly confidential. Volunteers who are not currently in psychiatric treatment, are drug-free and physically healthy should call: (214) 648-5351.

A Multicenter, Long-Term, Open-Label Study to Assess the Safety and Tolerability of Aripiprazole as Adjunctive Therapy in the Treatment of Outpatients with Major Depressive Disorder

Description:
We are conducting a clinical trial recruiting subjects with treatment-resistant depression. We are seeking adults who are experiencing an inadequate response to their current antidepressant medication. The trial assesses the efficacy and tolerability of a combination treatment using medications currently approved for depression and bi-polar illness. Participants receive study treatment at no cost, and are compensated $30 per visit for time and travel.

Transcranial Magnetic Stimulation (TMS) in the Treatment of Major Depression

Description:
This study is a trial of an outpatient, non-medication, non-invasive investigational treatment called Transcranial Magnetic Stimulation (TMS). TMS applies a magnetic field to the brain for a brief period of time. We are testing whether TMS can treat major depression. Participants will be randomly assigned to either active rTMS or sham (placebo) rTMS. If patients receive sham and do not improve, they have the option of receiving real TMS.

Description:
The University of Pittsburgh is seeking participants in a research study to be conducted at UPMC Shadyside's Center for Complementary Medicine (CCM) to determine how useful acupuncture is for treating depression.

CCM is seeking 60 individuals between the ages of 18 and 80 who have been diagnosed with mild to moderate depression. Participants will receive an evaluation of depression and acupuncture session at no charge. Upon completion of the study, subjects will receive a payment of $50.

Description:
Exercise may be an effective treatment for depression. However, it is not known whether exercise can be used to augment the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) in individuals with major depressive disorder (MDD). The University of Texas Southwestern Medical Center at Dallas and the Cooper Institute are conducting a 4-year study, funded by the NIMH, to evaluate whether 12 weeks of exercise training can induce remission of depression in partial responders to SSRIs. We are enrolling sedentary men and women (with MDD) suffering from significant depressive symptoms while taking an SSRI. Participants will receive free antidepressant medication and exercise training at the Cooper Institute (Dallas, TX).

Description:
"Pure" dysthymia is defined as a mild, chronic form of depression persisting for at least 2 years without periods of remission and not meeting criteria for a diagnosis of major depression. This research study aims to explore the responsiveness of dysthymia to a new SSRI. Treatment will be given for 12 weeks.

Eligibility:
Subjects must be English speaking in order to understand the diagnostic and outcome assessments. Subjects must be above the age of 18 and have a SCID confirmed DSM-IV diagnosis of dysthymic disorder without concurrent major depression. Individuals HAM-D score must be 12 or greater on the 24 item Hamilton Depression Rating Scale.

Description:
The purpose of this study is to determine whether psychotherapy is an effective treatment for patients with chronic depression who have not completely responded to antidepressant medication. Participants receive an initial trial of antidepressant medication for 8 to 12 weeks. Participants who continue to have depressive symptoms are randomly assigned to add Cognitive Behavioral Analysis System of Psychotherapy (CBASP) or supportive therapy to their medication regimens or to continue pharmacotherapy alone for additional 12 weeks.

Eligibility:
Participants must be between the ages of 18 Years - 75 Years and may be either female or male.

Inclusion Criteria:

Description:
Older people who feel depressed and who are having trouble with getting started and making decisions sometimes are affected by executive dysfunction. This combination presents special treatment problems that have not been effectively treated with medication. Researchers at the Weill Medical College of Cornell University and the Department of Psychiatry at the University of California San Francisco are enrolling local volunteers 60 years of age and older in a clinical trial that will compare two non-pharmaceutical psychotherapies, both of which have shown early positive results. Patients who qualify and volunteer for the study will be randomly assigned to receive 12 weeks of one of the two therapies without charge. As part of the study, they will also be interviewed during the course of therapy and receive monetary compensation for their participation.

Eligibility:
Eligible participants must be 60 years of age, speak English, live in Westchester County, NY or the San Francisco bay area, and cannot take antidepressant medication while participating in this trial.

Description:
The National Institute of Mental Health (NIMH) is looking for volunteers to help better understand the causes of depression. The research study includes 6 outpatient visits at the NIH Clinical Center in Bethesda, MD. The study includes medical and psychiatric evaluations. Financial compensation and transportation reimbursement provided.

You May Be Eligible if You Are:
-between the ages of 18-60
-not currently depressed
-medication-free
-otherwise medically healthy

Description:
- SSRI, Cognitive Behavioral Therapy, Combination or Placebo
- Diagnosis of Major Depressive Disorder (MDD)
- 12 weeks treatment; 6-month extension for responders; 1 year follow-up
- Outpatient only (no inpatient or incarcerated)

Contact:
Hyung Koo (410) 614-4001 or Nicole Simone (410) 614-4460

Description: Researchers at the University of Pittsburgh School of Medicine and the National Institute of Mental Health (NIMH) are conducting a study to increase the understanding of serotonin function in the brain during major depression. Participants who qualify will undergo two kinds of brain scans: magnetic resonance imaging (MRI) and positron emission tomography (PET.) After the initial series of scans, participants will be prescribed an antidepressant. After taking the drug for 10 weeks, participants will receive a second PET scan. Participants must be between 18 and 59 years old and have a relative who has been treated for depression. In addition, participants must be medically cleared for the imaging and have no history of substance abuse.

Description: Depression Studies at New York State Psychiatric Institute, Columbia Presbyterian Medical Center Mid and Late Life Depression Clinic. Our clinic has a number of ongoing studies using medication to treat depression in persons over 45 years of age. Since these studies are funded by NIH or pharmaceutical industries, there is no charge for medication or the treatment by psychiatrists or social workers. We are currently examining several types of depression including melancholia, dysthymia, and atypical depression as well as depression with cognitive impairment. Our testosterone studies are available for men over 18 years of age. We offer free evaluation and treatment. Participation is voluntary; confidentiality is assured.

Study participants must be between the ages of 18 to 75 and have a primary diagnosis of major depressive disorder.

Study participants will be hospitalized at the Hampstead Hospital, Hampstead, NH during study drug administration and be treated as outpatients for the following 49 days.

Contact:
Joanne Whelan
Corcept Therapeutics
Phone: (617) 734-2220
Email: AccessTrials@AOL.com

Anxiety Study

Is Anxiety interfering with your life? If you are often worried, irritable, anxious, upset and can’t concentrate you may have anxiety disorder. CNS Clinical Trials is conducting a research study for anxiety disorder. CNS Clinical Trials is conducting a research study for anxiety. Interested individuals must be between 18 and 65 years old. Qualified study participants may receive investigational study medication and study related physical exams at no cost. Compensation for your travel may be provided. If anxiety is taking over your life, see if you can join a Clinical research study at CNS Clinical Trials.

Contact:
Jane Harper
727-576-8474
narnold@cnsmail.com

Deadline: Open

Anxiety Study

Are you afraid or embarrassed to participate in social situations such as meeting new people, dealing with authority figures, attending parties, making phone calls or eating and drinking in public? Is your home the only place that you feel completely comfortable? Do social situations produce physical discomforts such as sweating, nervousness, stuttering, blushing, hand tremors or a dry mouth? Are you feeling socially isolated? If so, you may be suffering from Social Anxiety Disorder. CNS Clinical Trials is looking for volunteers between the ages of 18-65 to participate in a research study of an investigational medication for social anxiety. Study participants may receive study medication and physical exams at no cost.

Contact:
Jane Harper
727-576-8474
narnold@cnsmail.com

Deadline: Open

Parents of Depressed Adolescents

I am seeking volunteer participants to complete an anonymous web-based survey of parental attitudes concerning depression in order to better understand how relationships are affected by having a depressed child in the home. The study includes questions about your child’s depression, your relationship with your child, and what you believe about depression. Although there are no direct benefits to you, your participation in this study will provide information that could lead to greater understanding of depression and help with designing new treatment models for depression. This study will be published as a dissertation and the results may be used in scholarly journals.

Your participation is voluntary, and your responses are anonymous. The survey does not ask you for any information that would identify you. Data are transmitted to a secure server. There is no penalty for not volunteering or for discontinuing at any time, and there are no known risks for participants. It should take 15-20 minutes to complete.

I strongly encourage you to take part in the survey and contribute to the development of better methods of assessment that can be utilized to make treatment decisions and better methods of treatment that focus specifically on each individual’s problems.

You may access the survey by going to the website below:

http://survey.emich.edu/jmcdowell/jmcdowell_depression.htm

All participant users who visit this Web site are prohibited from digitally copying, saving, or temporarily storing the Test and may not use the Test for any purpose other than completing the administration.

Any concerns or questions can be addressed to: jmcdowell4@emich.edu or cfreedman@emich.edu (Committee Chair). This study has been reviewed and approved by the University Human Subjects Review Committee. You may contact EMU Human Subjects Committee co-Chairs for any questions regarding the consent agreement and research protocol approval procedures (Dr. Patrick Melia and Dr. Steve Pernecky, 734-487-0379).

To Love & To Work

This research explores people's love lives and work lives, what they find most and least satisfying, what people would change, and why. The research also explores the importance people place on their feelings and thoughts when making decisions about these areas of their lives. Any persons who would like to contribute their own experiences and opinions to this research, or would like more information about the research, are welcome to visit the link below.

http://www.media.swin.edu.au/surveyor/survey.asp?s=01042135134253247146

Study on how bipolar disorder affects people's lives

If you are interested in participating and want to find out if you qualify for this study, please call the phone number or visit the web link listed here:

Call: 1-866-MED-POLL (toll-free)

or visit: www.prescriptionstudy.com

If you qualify for this study you will be compensated for your time and effort. Your participation is greatly appreciated.

This is not a clinical study. It is purely for research purposed and there will be no attempts to sell you anything or influence you in any way. All of your responses will remain confidential.

Stigma and Discrimination Survey

The Center for Psychiatric Rehabilitation at Boston University is conducting a brief anonymous survey about the stigma and discrimination people in recovery encounter in everyday life situations and about the ways they deal with such negative experiences. Findings from this survey will inform the development of a new intervention intended to foster the competence of people in recovery to cope with stigma and discrimination. If you are interested in contributing to this study, please complete a brief anonymous internet survey and/or let others know about this study. To find out more about the
survey and to participate, visit the following link: http://www.bu.edu/cpr/stigmasurvey/

Internet Peer Support Research Study For People With Mental Illnesses

A study on new forms of peer-support is looking for mental-health consumers interested in participating in an internet-based support group. The UPenn Collaborative on Community Integration is looking for participants who will use e-mail for peer/recovery support. This group can connect you 24-hours a day, 7-days a week to a community of supportive peers, in your own home or anywhere you can access the Internet!

We are looking for people who:

Have been diagnosed with a mental illness, other than anxiety disorders
Have access to a computer and the Internet
Would consider using the Internet for support and information
Are United States Residents
Are fluent in English

Participants will be compensated for their participation in this study.

If you want to participate or would like more information, please email us at the following address: mhsupp@mail.med.upenn.edu

Genetics and Psychosis: Websurvey of affected individuals and their family members

Description:
In the field of genetic research into psychiatric illness, this is a very exciting time. The understanding of the genetic contributions to psychiatric disorders is progressing rapidly. However, it seems that this understanding is not filtering through to affected families as efficiently as it could be. To date, no large scale studies have been undertaken to assess affected families perceptions of genetic risks for psychosis, their attitudes towards predictive genetic testing for psychosis, and their needs for education and information about the genetics of psychosis. The purpose of this study is to assess affected families attitudes towards, knowledge of, and risk perception relating to genetic issues. The study aims to evaluate the need for genetic information, education, and resources for families of people with psychosis.

The UIC NRTC announces its Online Survey about Mental Health and Personal Choice, a survey of people who have used mental health services or have experienced emotional or mental health problems. We would like to know how much control they have over their lives and important life decisions, such as where they live, what kind of work they do, and how they spend their money. We'd also like to know about the role of computers and the Internet in their lives. The results of this survey will help to inform the mental health field about these important topics. The survey will take about 10 to 20 minutes to complete and is voluntary and anonymous. No one will be asked to identify themselves.

Researchers at the University of Iowa and San Jose State University are conducting a survey about patients' experiences with talking to physicians about health information they find on the internet. The entire survey should take you approximately 15 minutes to complete. Your answers will not be linked to your identity or to your email address in any way. Only the researchers will see the answers you provide.

Description:
Ever been flooded with anxiety? Does your heart start pounding; start shaking or sweating; feel like you're choking or short of breath; feel dizzy, nauseous or lightheaded; even feeling afraid you might die? If you re afraid of another attack occurring and these come out of the blue you may be suffering from an anxiety disorder called panic disorder. The National Institute of Mental Health (NIMH) is seeking volunteers to participate in a brain imaging research study and/or a treatment study. The treatment trial is trying to find out if a combination of medications can rapidly improve symptoms. Study participation includes a thorough mental health assessment, commonly used psychiatric medications and compensation for brain imaging.

You May Be Eligible if You Are:
-over 18 years old
-not currently taking any psychiatric medications

Description:
Are you a trauma survivor? Have you lived through a life threatening event such as physical/sexual abuse, injury, accident, or disaster? Volunteers are needed for research of the differences in how people respond to and cope with a traumatic experience. Studies involve brain imaging, measurement of stress hormones, and a free trial of commonly used medications for eligible participants. Compensation available for select studies. Travel reimbursement or cab service available.

Description:
Doctors at the (National Institute of Mental Health (NIMH) are seeking healthy volunteers to participate in studies on mood and anxiety disorders. Participation in these studies may include a physical exam, lab work, brain imaging, medication and/or psychological interviews. The studies are conducted at the NIH Clinical Center in Bethesda, Maryland. Compensation is provided.

You May Be Eligible if You Are:
-between the ages of 18-65
-medically healthy
-free of current or past history of psychiatric illness
-free of a history of head trauma with a loss of consciousness
-not currently taking any medication

Description:
- SSRI, Cognitive Behavioral Therapy, Combination or Placebo
- Diagnosis of Separation Anxiety Disorder, Social Phobia, or Generalized Anxiety Disorder
- 12 weeks, 6-month treatment maintenance period for responders to all three active treatments.
- Exclusions are primary or co- primary diagnosis of Panic Disorder, OCD, PTSD, Selective Mutism, or Conduct Disorder.
- No history of a lifetime psychotic disorder, major neurologic disease or major medical illness.

Description:
- Diagnosis of ADHD
- 10 sessions of parent training
- 16 months, combination of open Methylphenidate (MPH) treatment & double-blind placebo controlled MPH treatment, depending on phase of study
- 3-5 year olds must be enrolled in at least 2 half-days of structured preschool or daycare

Conte Center For The Neuroscience of Depression
Brain Autopsy Program
Many people are already familiar with organ donations involving the corneas, kidneys, or the heart; but most people do not ordinarily think of brain donation. Donation of brain tissue for research is an extraordinary gift that few people think of. For more information about this program, click here.

Bipolar Depression Research Study

Contact:
Anne Chewning
410-502-2334
ac@jhmi.edu

Deadline: Open

The Genetics of Bipolar Disorder

Contact:
Catherine Conroy
215-746-3656
conroycg@mail.med.upenn.edu

Deadline: 12/2008

Research study for children and adolescents with Bipolar I Disorder

Description:
Four-week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of an investigational drug in children and adolescents ages 10-17 with Bipolar I Disorder (manic or mixed). Site location: Newport Beach, CA.

Contact:
Sheila Mangel
949-640-7743
sheilsun@aol.com

Deadline: Open

A Multi-center Study on the Efficacy and Safety of an Atypical Neuroleptic in Combination with a Mood Stabilizer in the Long-term Maintenance Treatment of Patients with Bipolar I Disorder with a Recent Manic or Mixed Episode

Research study for individuals who have Bipolar disorder with major depressive episodes

Randomized, placebo-controlled trial of a new medication for treatment resistant depression

Contact:
Mara Steinbugler
212-241-6383
mara.steinbugler@mssm.edu

Deadline: Open

Anxiety Study

Anxiety Study

Bipolar Depression Research Study

Contact: Anne Chewning 410-502-2334 ac@jhmi.edu

Deadline: Open

The Genetics of Bipolar Disorder

Contact: Catherine Conroy 215-746-3656 conroycg@mail.med.upenn.edu

Deadline: 12/2008

Research study for children and adolescents with Bipolar I Disorder

Description: Four-week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of an investigational drug in children and adolescents ages 10-17 with Bipolar I Disorder (manic or mixed). Site location: Newport Beach, CA.

Contact: Sheila Mangel 949-640-7743 sheilsun@aol.com

Deadline: Open

A Multi-center Study on the Efficacy and Safety of an Atypical Neuroleptic in Combination with a Mood Stabilizer in the Long-term Maintenance Treatment of Patients with Bipolar I Disorder with a Recent Manic or Mixed Episode

Research study for individuals who have Bipolar disorder with major depressive episodes

Randomized, placebo-controlled trial of a new medication for treatment resistant depression

Contact: Mara Steinbugler 212-241-6383 mara.steinbugler@mssm.edu

Deadline: Open

Anxiety Study

Anxiety Study

Contact:
Anne Chewning
410-502-2334
ac@jhmi.edu

Contact:
Catherine Conroy
215-746-3656
conroycg@mail.med.upenn.edu

Description:
Four-week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of an investigational drug in children and adolescents ages 10-17 with Bipolar I Disorder (manic or mixed). Site location: Newport Beach, CA.

Contact:
Sheila Mangel
949-640-7743
sheilsun@aol.com

Contact:
Mara Steinbugler
212-241-6383
mara.steinbugler@mssm.edu